人工合成胰岛素的精神代代相传——纪念我国人工合成结晶牛胰岛素50周年

doi:10.3866/pku.DXHX20150201

Abstract

Abstract:

From 1958 on, after going through great efforts for more than six years, Chinese scientists obtained successfully the crystals of total synthesis of bovine insulin in September, 1965. That was the first human synthesized crystalline protein with biological activity in the world. As a crucial step toward understanding and exploring the secrets of life, it stands as one of the major milestones in history of the development of natural sciences in China. In accomplishing the great achievement, the Chinese scientists dared to undertake difficult tasks and scale the heights of science. Besides, they are filled with the spirit of taking the whole situation into consideration; seeking group coorperaton; persisting hard struggle; regardless of personal fame and gain; being earnest and realistic; and having a rigorous attitude for scientific research. All these fine qualities are worthy of further development and being carried on from generation to generation.

Key words: Bovine insulin, Total synthesis, Protein

Tang Kaluo. 50th Anniversary of the Total Synthesis of Bovine Insulin & Its Spiritual Heritage[J].University Chemistry, 2015, 30(2): 1-5.

References

[1] 叶蕴华. 大学化学,2011,25(增刊):19
[2] Best C H,Banting F G. Am J Physiol,1922,62:162
[3] Craig J J,Harfenist E J,Craig L C. J Am Chem Soc,1952,74:3087
[4] Sanger F. Biochem J,1955,60:556
[5] Harris J I,Sanger F,Naughton M A. Arch Biochem Biophys,1956,65:427
[6] 熊卫民,王克迪. 合成了一个蛋白质. 济南:山东教育出版社,2005
[7] Kung Y T(龚岳亭),Du Y C(杜雨芲),Huang W T(黄维德),Chen C C(陈常庆),Ke L T(葛麟俊),Hu S C(胡世全),Jiang R Q(蒋荣庆),Chu S Q(朱尚权),Niu C I(钮经义),Hsu J Z(徐杰诚),Chang W C(张伟君),Cheng L L(陈玲玲),Li H S(李鸿绪),Wang Y (汪猷),Loh T P(陆德培),Chi A H(季爱雪),Li C H(李崇熙) ,Shi P T(施溥涛) ,Yieh Y H(叶蕴华),Tang K L(汤卡罗), Hsing C Y(邢其毅). Total Synthesis of Crystalline Insulin. Sientia Sinica,1965,14:1710(简报);Sientia Sinica,1966,15:544(英文全文);科学通报,1966,17:241(中文全文)
[8] McElheny V K. Science,1966,153:281
[9] 恩格斯. 自然辩证法. 中共中央马克思恩格斯列宁斯大林著作编译局译. 北京:人民出版社,1971
[10] 邹承鲁,梁栋材,王贵海,等口述. 熊卫民整理. 从合成蛋白质到合成核酸. 长沙:湖南教育出版社,2009
[11] Katsoyannis P G,Tometsko A,Fukuda K. J Am Chem Soc,1963,85:2863
[12] Zhan H. Z Naturforsch,1963,18:1120
[13] Niu C I(钮经义),Kung Y T(龚岳亭),Huang W T(黄维德),Ke L T(葛麟俊),Chen C C(陈常庆),Chen Y C(陈远聪),Du Y C(杜雨芲),Jiang R Q(蒋荣庆),Zou C L(邹承鲁),Hu S C(胡世全),Chu S Q(朱尚权),Wang K Z(汪克臻). Partial Synthesis of Crystalline Bovine Insulin from Synthetic B-Chain and Natural A-Chain . Scientia Sinica,1965,14:1386;科学通报,1965(8):722
[14] Wang Y(汪猷),Hsu J Z(徐杰诚),Chang W C(张伟君),Cheng L L(陈玲玲), Li H S(李鸿绪),Hsing C Y(邢其毅),Shi P T(施溥涛),Loh T P(陆德培),Chi A H(季爱雪),Li C H(李崇熙),Yieh Y H(叶蕴华),Tang K L(汤卡罗). Partial Synthesis of Crystalline Bovine Insulin from Synthetic A-Chain and Natural B-Chain. Scientia Sinica,1965,14:1887;科学通报,1965(12):1111
[15] 杜雨芲,蒋荣庆,邹承鲁. 从胰岛素A 及B 链合成胰岛素郁. 生物化学与生物物理,1964,4:941;Scientia Sinica,1965,14:229
[16] 汪猷,季爱雪,陆德培,李崇熙,施溥涛,叶蕴华,汤卡罗,邢其毅. 含半胱氨酸多肽的研究芋. 牛胰岛素A 链带保护基的氨端九肽的合成. 化学学报,1966,32:68

50th Anniversary of the Total Synthesis of Bovine Insulin & Its Spiritual Heritage

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